Na-Desoxycholat [German]
sodium 3-α,12-α-dihydroxy-5-β-cholan-24-oate
CAS: 302-95-4
Molecular Formula: C24H41NaO4
Na-Desoxycholat [German] - Names and Identifiers
Na-Desoxycholat [German] - Physico-chemical Properties
| Molecular Formula | C24H41NaO4 |
| Molar Mass | 416.58 |
| Density | 1.012 at 20.07℃ |
| Melting Point | 357-365 °C |
| Boling Point | 547.1 °C at 760 mmHg |
| Specific Rotation(α) | 44 º (c=2, H2O) |
| Flash Point | >110°C (own results) |
| Water Solubility | 330 g/L (15 ºC) |
| Solubility | DMSO : 6.25 mg/mL (15.08 mM; Need ultrasonic) |
| Vapor Presure | 0Pa at 20℃ |
| Appearance | White crystalline powder |
| Color | Yellow-tan |
| Odor | Odorless |
| BRN | 3581950 |
| PH | 7.5-9.0 (20g/l, H2O, 20℃) |
| Storage Condition | room temp |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00064139 |
| In vitro study | Deoxycholic acid (DCA) and chenoDeoxycholic acid (CDCA), as the common ingredients of duodenal reflux, act synergistically in many physiological and pathological processes. The cells are repeatedly exposed to 100 μM CDCA and Deoxycholic acid at pH 5.5 for up to 120 min. To simulate chronic local recurrent disease in vitro, the gastric cancer cell line MGC803 is exposed to acidified medium (pH 5.5) containing 100 μM Deoxycholic acid and CDCA. An untreated log-growth MGC803 cell line is generated to be used as a control in normal pH media. After daily 10 min exposure to the acidified bile acids for 60 weeks, MGC803-resistant cells are able to survive and proliferate after 120 min exposure. |
Na-Desoxycholat [German] - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37 - Irritating to the respiratory system |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | FZ2250000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29181930 |
| Toxicity | LD50 orally in Rabbit: 1370 mg/kg |
Na-Desoxycholat [German] - Reference
| Reference Show more | 1. Jiang Yue, Sun Dandan, Yin Shouyu. Preparation and quality evaluation of ketoconazole solid lipid nanoparticles [J]. Medical Journal of Yanbian University, 2016(04):30-33. 2. Yan, J., hu, J., yang, R. and Zhao, W. (8/2018), A new nanofiber derived from bamboo leaves: enhanced physiological chemical properties and real tolerance of oil. Int J Food Sci Technol, 53: 2394-2404. https://d 3. Yan, Jiai, et al. "Innovative nanofibrillated cellulose from rice straw as dietary fiber for enhanced health benefits prepared by a green and scale production method." ACS Sustainable Chemistry & Engineering 6.3 (2018): 3481-3492.https://doi.org/10.1021/ac 4. Kehao Huang, Bin Du Baojun Xu,Alterations in physicochemical properties and bile acid binding capacities of dietary fibers upon ultrafine grinding,Powder Technology,Volume 326,2018,Pages 146-150,ISSN 0032-5910,https://doi.org/10.1016/j.powtec.2017. 5. Wang, Fangyuan, et al. "Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study." International journal of pharmaceutics 577 (2020): 119046.https://doi.org/10.1016/ 6. [IF=8.198] Jiai Yan et al."Innovative Nanofibrillated Cellulose from Rice Straw as Dietary Fiber for Enhanced Health Benefits Prepared by a Green and Scale Production Method."Acs Sustain Chem Eng. 2018;6(3):3481-3492 7. [IF=6.475] Li Wang et al."Bilosomes as effective delivery systems to improve the gastrointestinal stability and bioavailability of epigallocatechin gallate (EGCG)."Food Res Int. 2021 Nov;149:110631 8. [IF=3.638] Xiangquan Zeng et al."In vitro studies on the interactions of blood lipid level-related biological molecules with gallic acid and tannic acid."J Sci Food Agr. 2019 Dec;99(15):6882-6892 9. [IF=1.902] Zhaohong Xi et al."Explore the effects of Shidan granules on chronic atrophic gastritis using LC-MS based plasma metabolomics study."Biomed Chromatogr. 2021 Sep;35(9):e5129 |
Na-Desoxycholat [German] - Standard
Authoritative Data Verified Data
This product is 3a,12a-two meridian-5p-bile trace -24-sodium acetate. Calculated as the dried product, the content of C24H39Na04f was less than 97. 0%.
Last Update：2024-01-02 23:10:35
Na-Desoxycholat [German] - Trait
Authoritative Data Verified Data
- This product is white or off-white powder.
- This product is soluble in water or ethanol, insoluble in ether.
specific rotation
take this product, precision weighing, add water to dissolve_quantitative dilution to make about 20mg per lm l solution, according to the law (General 0621), specific rotation of 40. 0 ° to 45 °. 0 degrees.
Last Update：2022-01-01 11:25:17
Na-Desoxycholat [German] - Differential diagnosis
Authoritative Data Verified Data
- Take 10 mg of this product, add 1 drop of sulfuric acid lm l and formaldehyde to dissolve, place for 5 minutes, then add 5ml of water to generate blue-green suspended matter.
- The infrared absorption spectrum of this product should be consistent with that of the reference substance of sodium deoxycholate (General Rule 0 4 0 2).
- identification reaction of sodium salt of this product (General Rule 0 3 0 1).
Last Update：2022-01-01 11:25:17
Na-Desoxycholat [German] - Exam
Authoritative Data Verified Data
sodium
take an appropriate amount of sodium standard solution and dilute it quantitatively with water to make each lm l containing 0, 16jLtg and 0. 4 Net, 0. 8 ^ tg. 1.0/ig, 1. 2pg solution, as a reference solution; Take this product 0. 14g, precision weighing, platinum crucible, slowly heated to complete carbonization, cool, add sulfuric acid 0 .5M l to wet, low temperature heating to sulfuric acid vapor removal after burning at 600°C to a white gray matter, cool, precision Force 1 into hydrochloric acid lm l dissolved and quantitatively transferred to 100ml measuring flask, diluted with water to the scale, shake, precision take lm l 100ml measuring flask, diluted with water to the scale, as a test solution. The blank solution was prepared by the same method, and was measured and calculated at the wavelength of 589. O nm by atomic absorption spectrophotometry (General Rule 0 4 0 6 first method). Based on the dry product, the sodium content should be 5.0% ~ 6.1%.
clarity and color of solution
take 0.5g of this product, Add 10ml of water to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ) , the solution should be clear and colorless. In case of color development, it shall not be deeper than the yellow No. 1 Standard Colorimetric solution (General rule 0901).
loss on drying
take this product, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 5.0% (General rule 0831).
Heavy metals
take l.O g of this product, put it in a platinum crucible, and check it according to law (General rule 0821 second law). The heavy metal content shall not exceed 20 parts per million.
arsenic salt
take this product l . O g, add 500% magnesium nitrate ethanol solution, light the ethanol, slowly heat to ash, if there is still carbonized, you can add a small amount of nitric acid wet, continue to heat (~ 60(TC)) after complete ashing, cool down, add water 21ml to dissolve, add hydrochloric acid 5ml, check according to law (General rule 0822 first law), should comply with the regulations (0. 0002%).
Last Update：2022-01-01 11:25:18
Na-Desoxycholat [German] - Content determination
Authoritative Data Verified Data
take this product about 0.3g, precision weighing, add anhydrous formic acid 5 m l to dissolve, add glacial acetic acid 3 5 m l, potentiometric titration (General Rule 0 7 0 1 ) , with perchloric acid titration solution (O . lm o l/L) titration, and the results of the titration were corrected with a blank test. Each l of perchloric acid titration solution (0. l m o l/l) corresponds to 41. 46mg of C24 H39 na04.
Last Update：2022-01-01 11:25:18
Na-Desoxycholat [German] - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers, etc.
Last Update：2022-01-01 11:25:19
Na-Desoxycholat [German] - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:19
![Na-Desoxycholat [German]](http://res.chembk.com/assets/str/2d/3/30/302-95-4.png)
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